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. 2022 Dec 31;12(1):173. doi: 10.3390/cells12010173

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Clinical significance of cuproptosis regulators in ccRCC. (A) Expression levels of cuproptosis regulators between ccRCC and normal kidney tissues. (B) Methylation on promoter regions of cuproptosis regulators between ccRCC and normal kidney tissues. (C–I) High expression of FDX1 (C), DLAT (D), DLD (E), PDHB (F), LIAS (G), LIPT1 (H), and PDHA1 (I) predicted longer survival in ccRCC according to Kaplan–Meier survival analyses. * p < 0.05, *** p < 0.001, **** p < 0.0001; n.s. = no significance.