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. 2023 Jan 3;15(1):312. doi: 10.3390/cancers15010312

Figure 2.

Figure 2

Dual neprilysin and angiotensin II receptor type 2 blockage by ARNi. Abbreviations: ACE—angiotensin-converting enzyme; Ang 1-7—angiotensin 1-7; Ang II—angiotensin II; ANP—atrial natriuretic peptide; ARB—angiotensin II receptor type 1 blocker; ATR1—angiotensin II receptor type 1; ATR2—angiotensin II receptor type 2; BNP—brain natriuretic peptide; cGMP—cyclic guanosine monophosphate; CNP—C-type natriuretic peptide; GC—guanyl cyclase; GTP—guanosine-5′-triphosphate; MasR—Mas receptor; NEP—neprilysin; NEPi—neprilysin inhibitor; NPR—natriuretic peptide receptor; PKG—protein kinase G.