Table A3.
Initial treatment response and site of disease progression.
| Variables | All Patients | No OP/RT | OP or RT | p-Value |
|---|---|---|---|---|
| Initial treatment response | ||||
| Progressive disease (PD) | 18 (10%) | 11 (10%) | 7 (9%) | 0.9521 |
| Stable disease (SD) | 26 (14%) | 14 (13%) | 12 (15%) | |
| Partial response (PR) | 139 (75%) | 80 (75%) | 59 (75%) | |
| Complete response (CR) | 3 (2%) | 2 (2%) | 1 (1%) | |
| Disease control rate | 168 (90%) | 96 (90%) | 72 (91%) | 0.7462 |
| Response rate | 142 (76%) | 82 (77%) | 60 (76%) | 0.9133 |
| Initial intracranial treatment response † | ||||
| Intracranial progressive disease (iPD) | 9 (6%) | 3 (3%) | 6 (8%) | 0.1141 |
| Intracranial stable disease (iSD) | 28 (18%) | 11 (13%) | 17 (24%) | |
| Intracranial partial response (iPR) | 76 (48%) | 44 (51%) | 32 (44%) | |
| Intracranial complete response (iCR) | 46 (29%) | 29 (33%) | 17 (24%) | |
| Intracranial disease control rate | 150 (94%) | 84 (97%) | 66 (92%) | 0.1846 |
| Intracranial response rate | 122 (77%) | 73 (84%) | 49 (68%) | 0.0185 |
| Site of disease progression | ||||
| Intracranial progression | 48 (26%) | 25 (23%) | 23 (29%) | 0.3757 |
| Extracranial progression | 21 (11%) | 12 (11%) | 9 (11%) | 0.9698 |
| Lung | 5 (3%) | 4 (4%) | 1 (1%) | 0.3027 |
| Pleural nodule/effusion | 7 (4%) | 3 (3%) | 4 (5%) | 0.4235 |
| Bone | 9 (5%) | 5 (5%) | 4 (5%) | 0.9024 |
| Liver | 2 (1%) | 1 (1%) | 1 (1%) | 0.8286 |
| Adrenal gland | 1 (1%) | 0 (0%) | 1 (1%) | 0.2432 |
| Other | 1 (1%) | 1 (1%) | 0 (0%) | 0.3889 |
† Initial intracranial treatment response was assessed for 159 patients. Data are presented as n (%). p-values are presented for results of the chi-squared test.