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. 2022 Dec 29;15(1):197. doi: 10.3390/cancers15010197

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pathway enrichment analysis of genes associated with responsiveness to PD-1 inhibitor treatment. (A) KEGG pathway terms related to intrinsic genes in LUAD. (B) KEGG pathway terms related to extrinsic genes in LUAD. (C) KEGG pathway terms related to intrinsic genes in LUSC. (D) KEGG pathway terms related to extrinsic genes in LUSC. (E) Correlation analysis between the intrinsic gene signature and other immune checkpoint targets. LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; PD-1, programmed cell death protein 1; TCGA, The Cancer Genome Atlas. * Spearman’s rank correlation coefficient.