Table 1.
Clinicopathological characteristics in all 334 HCC patients.
| Patients’ Characteristics | All Patients N = 334 |
Males N = 258 |
Females N = 76 |
|---|---|---|---|
| Age [years]; median (range) | 63 (26–77) | 63 (36–75) | 65 (26–77) |
| Cirrhosis; N (%) | 329 (98.5) | 254 (98.4) | 75 (98.7) |
| Alcoholic | 129 (38.6) | 115 (44.6) | 14 (18.4) |
| Viral | 120 (35.9) | 77 (29.8) | 43 (56.6) |
| Cholestatic and autoimmune | 48 (14.4) | 37 (14.3) | 11 (14.5) |
| NASH (non-alcoholic steatohepatitis) | 29 (8.7) | 23 (8.9) | 6 (7.9) |
| Metabolic | 3 (0.9) | 2 (0.8) | 1 (1.3) |
| Not present | 5 (1.5) | 4 (1.6) | 1 (1.3) |
| HCC treatment; N (%) | |||
| Liver transplantation | 299 (89.5) | 225 (87.2) | 74 (97.4) |
| Other | 35 (10.5) | 33 (12.8) | 2 (2.6) |
| HCC characteristics | |||
| AFP [ng/mL]; median (range) | 8.3 (0.9–5784) | 7.4 (0.9–5784) | 15.0 (1.9–1210) |
| Milan criteria; N (% of known) | 220 (65.9) | 168 (65.1) | 52 (68.4) |
| Microangioinvasion; N (% of known) | 128 (45.6) | 91 (43.8) | 37 (50.7) |
| Cholangiocarc. differentiation; N (% of known) | 18 (5.4) | 10 (4.6) | 8 (10.8) |
| Grade 1; N (% of known) | 37 (13.0) | 22 (10.3) | 15 (21.1) |
| Grade 2; N (% of known) | 154 (54.0) | 123 (57.5) | 31 (43.7) |
| Grade 3; N (% of known) | 94 (33.0) | 69 (32.2) | 25 (35.2) |
| Multiple primary tumor; N (%) | 57 (17.1) | 48 (18.7) | 9 (11.9) |
| Malignancy in 1st/2nd degree relatives; N (%) | 131 (39.2) | 99 (38.4) | 32 (42.1) |
| Diabetes; N (%) | 138 (41.3) | 117 (45.3) | 21 (27.6) |
| Obesity (BMI>30); N (%) | 94 (28.1) | 80 (31.0) | 14 (18.4) |
| Smoking; N (%) | 192 (57.5) | 161 (62.4) | 31 (40.8) |