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. 2022 Dec 27;15(1):154. doi: 10.3390/cancers15010154

Figure 2.

Figure 2

(a) Cell viability normalized to DMSO control in four B-ALL cell lines treated for 48 h with serial dilutions of CCIs (AZ82, Stattic) or chemotherapy drugs (Doxorubicin, Paclitaxel). IC50 value is indicated by the dashed line. (mean ± SEM, n = 3 experiments). (b) Correlation between % CA and IC50 from CCIs (AZ82, Stattic) or chemotherapy drugs (Doxorubicin, Paclitaxel) for four B-ALL cell lines. Heatmap is scaled by row Z-score, with Pearson r (vs. CA) values (bold) and the p-value (in parentheses) on the right side (Pearson r, * p < 0.05, ** p < 0.01). (c) Detection of bipolar and multipolar cell division in mitotic 289 mouse cells stained with γ-tubulin, Histone-H3, β-tubulin, and DAPI. Cells were incubated with 1 μM AZ82 for 5 h. Scale Bar = 5 μm. (d) Frequency of mitotic 289 cells with multipolar spindles incubated with 1 μM AZ82, 1 μM Stattic, or 1 μM DMSO for 5 h. (mean ± SD, n=3 experiments indicated by dots, >20 cells per bar, * p < 0.05, ** p < 0.01, One-way ANOVA).