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. 2022 Dec 27;15(1):154. doi: 10.3390/cancers15010154

Figure 4.

Figure 4

(a) Cell viability normalized to DMSO control in 18 primary B-ALL samples and 5 primary bone marrow stem cell samples treated for 48 h with serial dilutions of AZ82 or Doxorubicin. (mean ± SEM). (b) Correlation between %CA and IC50 from AZ82 or Doxorubicin for 18 primary B-ALL samples and 5 primary bone marrow stem cell samples. Heatmap columns are ordered by hierarchical clustering based on average linkage, and rows are scaled by Z-score. Pearson r (vs. CA) values (bold) and the p-value (in parentheses) are on the right side (Pearson r, *** p < 0.001). Primary sample ploidy (2n = Euploid, A = aneuploid, T+ = translocation aneuploid), and stage (N = none, Dx = initial diagnosis, R = relapse) are indicated below the heatmap.