Table 4.

Ongoing trials using immune cell therapy targeting HER2-positive mCRC.

Phase	NCT Number	Title	Status	Treatment	n	HER2 Status
I	NCT04319757	ACE1702 in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors	Recruiting	ACE1702	36	IHC 3+ or 2+
I	NCT03740256	Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors (VISTA)	Recruiting	HER2 specific CAR-T cell + CAdVEC	45	IHC 2+ or above
I	NCT04660929	CAR macrophages for the Treatment of HER2-Overexpressing Solid Tumors	Recruiting	CT-0508	18	HER2 positive

Abbreviations: IHC, immunohistochemistry; CAR, chimeric antigen receptor; mCRC, metastatic colorectal cancer.