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Scheme of polo-like kinase 1 (Plk1) mRNA translation. (A) Cytoplasmic polyadenylation element-binding protein 1 (CPEB1) represses the translation of CPE-containing mRNAs with short poly(A) tails, including Plk1 mRNA. Phosphorylated CPEB1 promotes the binding of the cleavage and polyadenylation specificity factor (CPSF) complex to the hexanucleotide sequence (AAUAAA). (B) In mouse oocytes, CPSF recruits poly(A) polymerase α (PAPα), which promotes polyadenylation.
