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. 2022 Dec 24;12(1):65. doi: 10.3390/cells12010065

Figure 7.

Figure 7

SNHG11/miR-7-5p/PLCB1 plays an inhibitory role in pancreatitis by inhibiting the p38MAPK signaling pathway. (A) The bubble chart shows a significant enrichment of the KEGG pathway by PLCB1-related ceRNA genes. (B–E) In AR42J and HPDE6-C7 cells, the high expression of SNHG11 and PLCB1 could inhibit the expression of p-P38MAPK and the activation of the MAPK signaling pathway, while the low expression of MiR-7-5p showed the same effect. (F,G) The effect of SNHG11 on rat models of AP was confirmed by HE staining, and representative images have been shown. (H,I) The expression of SNHG11 and miR-7-5p was assessed in different rat tissues(AP+empty vs. AP+SNHG11). (J–L) The expression of PLCB1 and p-P38MAPK was verified in different rat tissues (AP+empty vs. AP+SNHG11). The data are presented as means ± SDs, n = 3 each group, * p < 0.05; ** p< 0.01; between the indicated groups. (M) Schematic diagram of SNHG11/MiR-7-5p/PLCB1 affecting pancreatitis through activation of p38MAPK pathway.