Table 3.
Increased Nuchal Translucency and Prenatal/Postnatal Outcome-systematic review.
| Nuchal Translucency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Reference | Dimension (mm) |
Association | Miscarriages | Intrauterine Deaths | Live Births | Perinatal Death | Intellectual Disability | Major Childhood Morbidity |
| [52] | ≥3.5 | apparently isolated-euploid | 0/20 (0.00%) |
1/20 (5.00%) |
19/20 (95.00%) |
1/19 (5.26%) |
3/19 (15.79%) |
3/19 (15.79%) |
| [63] | ≥3.5 | unspecified-euploid | . | 5/33 (15.15%) |
28/33 (84.85%) |
. | . | . |
| [64] | ≥3.5 | unspecified-euploid | 4/420 (0.95%) |
. | . | . | 10/270 (3.70%) |
10/370 (2.70%) |
| [65] | ≥3.5 | unspecified-euploid | 6/52 (11.54%) |
. | 46/52 (88.46%) |
. | . | 6/46 (13.04%) |
| [66] | ≤3.0 | unspecified | 45/1395 (3.23%) |
19/1395 (1.36%) |
1305/1395 (93.55%) |
. | . | . |
| ≥3.0 | unspecified | 22/105 (20.95%) |
15/105 (14.29%) |
33/105 (31.43%) |
. | . | . | |
| 3.0–4.0 | unspecified | 10/52 (19.23%) |
5/52 (9.62%) |
28/52 (53.85%) |
. | . | . | |
| 4.0–5.0 | unspecified | 10/33 (30.30%) |
7/33 (21.21%) |
5/33 (15.15%) |
. | . | . | |
| 5.0–6.0 | unspecified | 2/15 (13.33%) |
3/15 (20.00%) |
0/15 (0.00%) |
. | . | . | |
| ≥6.0 | unspecified | 0/5 (0.00%) |
0/5 (0.00%) |
0/5 (0.00%) |
. | . | . | |
| [68] | ≥3.0 | associated-euploid | . | . | 741/834 (88.85%) |
. | . | 43/741 (5.80%) |
| 3–3.4 | associated-euploid | . | . | 562/611 (91.98%) |
. | . | 28/562 (4.98%) |
|
| 3.5–4.4 | associated-euploid | . | . | 141/157 (89.81%) |
. | . | 7/141 (4.96%) |
|
| 4.5–5.4 | associated-euploid | . | . | 30/38 (78.95%) |
. | . | 2/30 (6.67%) |
|
| 5.5–6.4 | associated-euploid | . | . | 5/11 (45.45%) |
. | . | 4/5 (80.00%) |
|
| ≥6.5 | associated-euploid | . | . | 3/17 (17.65%) |
. | . | 2/3 (66.76%) |
|
| [102] | ≥3.0 | unspecified | . | 0/46 (0.00%) |
31/46 (67.39%) |
3/31 (9.68%) |
. | 3/31 (9.68%) |
| [73] | ≥99ct | associated-euploid | . | 4/36 (11.11%) |
13/36 (36.11%) |
1/6 (16.67%) |
. | 6/13 (46.15%) |
| ≥99ct | apparently isolated-euploid | 2/70 (2.86%) |
1/70 (1.73%) |
63/70 (90.00%) |
. | . | 3/63 (4.76%) |
|
| [103] | ≥95ct | unspecified-euploid | 23/625 (3.68%) |
. | . | . | . | . |
| [80] | ≥3.5 | unspecified-euploid | 5/139 (3.60%) |
1/139 (0.72%) |
110/139 (79.14%) |
. | . | 7/110 (6.36%) |
| 3.5–4.4 | unspecified-euploid | 2/86 (2.33%) |
1/86 (1.16%) |
77/86 (89.53%) |
. | . | 3/77 (3.90%) |
|
| 4.5–5.4 | unspecified-euploid | 0/28 (0.00%) |
0/28 (0.00%) |
20/28 (71.43%) |
. | . | 2/20 (10.00%) |
|
| 5.5–6.4 | unspecified-euploid | 1/12 (8.33%) |
0/12 (0.00%) |
7/12 (58.33%) |
. | . | 1/7 (14.29%) |
|
| ≥6.5 | unspecified-euploid | 2/13 (15.38%) |
0/13 (0.00%) |
6/13 (46.15%) |
. | . | 1/6 (16.67%) |
|
| [82] | ≥95ct | unspecified | . | 9/239 (3.77%) |
210/239 (87.87%) |
. | . | 10/210 (4.76%) |
| 95ct–3.4 | unspecified | . | 2/139 (1.44%) |
135/139 (97.12%) |
. | . | 2/135 (1.48%) |
|
| 3.5–4.4 | unspecified | . | 2/52 (3.85%) |
46/52 (88.46%) |
. | . | 2/46 (4.35%) |
|
| 4.5–5.4 | unspecified | . | 2/19 (10.53%) |
16/19 (84.21%) |
. | . | 1/16 (6.25%) |
|
| 5.5–6.4 | unspecified | . | 0/8 (0.00%) |
4/8 (50.00%) |
. | . | 0/4 (0.00%) |
|
| ≥6.5 | unspecified | . | 3/21 (14.29%) |
9/21 (42.86%) |
. | . | 5/9 (55.56%) |
|
| [83] | ≥95ct | unspecified | 7/149 (4.70%) |
. | 110/149 (73.83%) |
. | . | . |
| 95ct–3.4 | unspecified | 1/82 (1.22%) |
. | 71/82 (86.59%) |
. | . | . | |
| 3.5–4.4 | unspecified | 2/43 (4.65%) |
. | 35/43 (81.40%) |
. | . | . | |
| 4.5–5.4 | unspecified | 0/7 (0.00%) |
. | 2/7 (28.57%) |
. | . | . | |
| 5.5–6.4 | unspecified | 3/8 (37.50%) |
. | 1/8 (12.50%) |
. | . | . | |
| ≥6.5 | unspecified | 1/19 (5.26%) |
. | 1/19 (5.26%) |
. | . | . | |
| [84] | 2.5–4.4 | unspecified | 4/33 (12.12%) |
0/33 (0.00%) |
20/33 (60.61%) |
. | . | . |
| 4.5–6.4 | unspecified | 1/8 (12.5%) |
0/8 (0.00%) |
1/8 (12.50%) |
. | . | . | |
| ≥6.5 | unspecified | 2/13 (15.38%) |
4/13 (30.77%) |
1/13 (7.69%) |
. | . | . | |
| [85] | ≥99ct | unspecified-euploid | 1/179 (0.56%) |
5/179 (2.79%) |
162/179 (90.50%) |
. | . | 18/162 (11.11%) |
| [86] | ≥4.0 | unspecified | . | 2/89 (2.25%) |
68/89 (76.40%) |
. | 4/64 (6.25%) |
4/68 (5.88%) |
| [87] | ≥6.5 | unspecified-euploid | 6/27 (22.22%) |
. | 8/27 (29.63%) |
. | . | . |
| [88] | ≥95ct | unspecified-euploid | . | 10/103 (9.71%) |
87/103 (84.47%) |
. | . | 10/87 (11.49%) |