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Thermodynamic parameters of peptide-MAb binding interactions as determined by ITCa
| MAb | Peptide | Kb (107 mol−1) | ΔHb (kJ mol−1) |
|---|---|---|---|
| SP5.2 | SPf66mon | 7.5 (1.1) | −46.1 (0.3) |
| 35.1mon | 0.5 (0.1) | −20.3 (0.6) | |
| SP8.18 | SPf66mon | 6.2 (2.1) | −62.2 (1) |
| 35.1mon | 0.2 (0.04) | −16.3 (0.4) |
Mean values for ΔHb and Kb (standard deviations shown in parentheses) were determined from a nonlinear least-squares fit of the heat exchanged per injection as a function of total injected peptide using Microcal ORIGIN software.
