Table 3.
Clinical characteristics (mean values and standard deviations) and sputum inflammatory measurement concentrations (logarithmically transformed median values and interquartile range) in the subjects with isolated outer dynein arm defects and inner dynein arm/microtubular disorganizations defects
| ODA (n = 36) | IDA/MTD (n = 26) | P Value | |
|---|---|---|---|
| Clinical characteristics | |||
| Age, yr | 14.9 (4.8) | 13.0 (4.4) | 0.10 |
| FEV1% predicted | 89.5 (14.8) | 71.5 (21.0) | <0.01 |
| Weight percentile | 64.4 (27.7), n = 32 | 47.3 (28.7), n = 24 | 0.03 |
| Body mass index percentile | 62.5 (31.0), n = 32 | 50.8 (29.1), n = 24 | 0.16 |
| Negative culture, n (%) | 25 (69) | 7 (30) | <0.01 |
| Haemophilus influenzae, n (%) | 3 (8) | 8 (31) | 0.04 |
| Staphylococcus aureus, n (%) | 7 (19) | 10 (38) | 0.15 |
| Streptococcus pneumoniae, n (%) | 3 (8) | 4 (15) | 0.44 |
| Moraxella catarrhalis, n (%) | 0 (0) | 2 (8) | 0.17 |
| Pseudomonas aeruginosa, n (%) | 2 (6) | 1 (4) | 0.99 |
| Protein analyte concentrations, median (IQR) | |||
| NE log μg/ml | 1.6 (1.0–1.9) | 1.6 (1.3–2.0) | 0.60 |
| MMP-9 log ng/ml | 4.0 (3.6–4.3) | 3.8 (3.5–4.1) | 0.27 |
| IL-1β log pg/ml | 3.9 (3.0–4.1) | 3.6 (2.7–4.1) | 0.61 |
| IL-6 log pg/ml | 1.8 (1.5–2.2) | 1.8 (1.5–2.2) | 0.93 |
| IL-8 log pg/ml | 5.3 (4.8–5.5) | 5.1 (4.9–5.6) | 0.66 |
| TNF-α log pg/ml | 2.4 (1.9–2.9) | 2.4 (1.7–3.1) | 0.94 |
| LTB4 log pg/ml | 3.6 (3.5–3.9) | 3.5 (3.4–3.6) | 0.06 |
Definition of abbreviations: FEV1 = forced expiratory volume in 1 second; IDA = inner dynein arm; IL = interleukin; IQR = interquartile range; LTB4 = leukotriene B4; MMP = matrix metalloproteinase; MTD = microtubular disorganization; NE = neutrophil elastase; ODA = outer dynein arm; TNF = tumor necrosis factor.