Table 1.
Cohort characteristics
| Variable | Overall (N = 7,037) |
No Triglycerides Measured (n = 5,313) |
Low Triglyceride* (n = 1,365) |
High Triglyceride* (n = 359) |
|---|---|---|---|---|
| Age (yr), mean (SD) | 61.5 (15.2) | 61.5 (15.2) | 61.52 (14.3) | 55.54 (13.7) |
| Sex (female), n (%) | 3,040 (43.2) | 2,328 (43.8) | 579 (42.4) | 133 (37.0) |
| Race (Black), n (%) | 2,192 (31.1) | 1,709 (32.2) | 380 (27.8) | 103 (28.7) |
| Ethnicity (not Hispanic), n (%) | 3,747 (53.2) | 2,847 (53.6) | 729 (53.4) | 171 (47.6) |
| Body mass index, mean (SD) | 30.0 (9.3) | 29.6 (9.3) | 30.5 (9.1) | 33.4 (9.1) |
| ICU type (medical), n (%) | 3,647 (51.8) | 2,728 (51.3) | 694 (50.8) | 225 (62.7) |
| Sars-CoV-2–positive, n (%) | 672 (9.5) | 314 (5.9) | 217 (15.9) | 141 (39.3) |
| Propofol days before first triglyceride measurement, median (IQR) | 1.78 (0.5–4.8) | n/a | 1.58 (0.4–4.7) | 2.32 (0.8–5.4) |
| Propofol days before highest triglyceride measurement, median (IQR) | 2.49 (0.7–6.5) | n/a | 2.02 (0.59–5.7) | 4.77 (2.0–9.1) |
| Cumulative propofol dose (g), median (IQR) | 12.9 (5.8–29.0) | 10.5 (4.9–22.5) | 22.4 (10.3–46.1) | 49.8 (27.6–86.3) |
| Receipt of continuous paralytics before triglyceride measurement, n (%) | 1,120 (15.9) | 0 (0.0) | 837 (61.3) | 283 (78.8) |
| Days hospitalized before mechanical ventilation, median (IQR) | 0.8 (0.2–4.0) | 0.8 (0.3–4.0) | 0.8 (0.2–3.9) | 0.9 (0.2–4.3) |
| APACHE-III score, mean (SD) | 63.9 (23.5) | 62.8 (23.8) | 66.3 (22.2) | 70.4 (22.8) |
| Ventilator d in survivors | 2.44 (0.78–6.95) | 1.97 (0.67–5.42) | 5.35 (1.63–12.67) | 11.35 (5.87–21.09) |
| ICU length of stay in hospital survivors (d), median (IQR) | 6.1 (3.3–11.7) | 5.3 (3.0–9.9) | 9.4 (5.0–16.7) | 15.8 (9.8–24.0) |
| Hospital length of stay in hospital survivors (d), median (IQR) | 18.4 (10.4–32.7) | 16.6 (9.5–29.1) | 25.1 (15.0–43.7) | 35.9 (21.2–55.8) |
| Hospital mortality, n (%) | 2,279 (32.4) | 1,569 (29.5) | 513 (37.6) | 197 (54.9) |
Definition of abbreviations: APACHE = Acute Physiology and Chronic Health Evaluation; ICU = intensive care unit; IQR = interquartile range; Sars-CoV-2 = severe acute respiratory syndrome coronavirus 2; SD = standard deviation.
*
Reflects maximum triglyceride measurement.