Table 2.
Characteristics of included studies.
| S. No | Study ID | Design | Setting | Age | Follow Up | Subjects | Patient Important Outcome | ||
|---|---|---|---|---|---|---|---|---|---|
| 1. | Mindachew et al., 2014 [24] | Qualitative | Hospital | N/A | N/A | 12 heath professional | barriers | Lack of patient empowerment and proper counseling on IPT, weak patient/healthcare provider relationship, lack of patient information, low reinforcement by health officials and stakeholders to strengthen IPT uptake and adherence forgetfulness, patient IPT non-adherence, and non-disclosure of HIV zero-status. | |
| 2. | Yirdaw et al., 2014 [12] | Retrospective cohort | Hospitals (n = 5) | Mean (30 years) | 2 years | 5407 patients | IPT before ART | aHR = 0.18, 95% CI = 0.08–0.42 | |
| IPT before ART’ | HR = 0.25, 95% CI = 0.11–0.59 | ||||||||
| IPT and ART | aHR = 0.20,95% CI = 0.10–0.42 | ||||||||
| IPT and ART | HR = 0.36; 95% CI = 0.17–0.74 | ||||||||
| IPT only | HR = 0.24, 95% CI = 0.13–0.44 | ||||||||
| IPT after ART | HR = 0.19, 95% CI = 0.11–0.34 | ||||||||
| TB incidence | 295 | ||||||||
| 3. | Assebe et al., 2015 [17] | Retrospective cohort study | Hospital | N/A | Mean 24.1 months | 588 | Overall TB incidence | 49 | |
| IPT 294 | No IPT 294 | Overall TB incidence | 3.78 cases per 100 PY (95% CI: 2.85, 4.99 cases per 100 PY) | ||||||
| Incidence of TB among IPT Plus ART | 2.22 cases per 100 PY (95% CI: 1.29, 3.82 cases per 100 PY) | ||||||||
| Incidence of TB among ART alone | 5.06 cases per 100 PY (95% CI: 3.65, 7.02 cases per100 PY) | ||||||||
| Incidence of TB among IPT Plus ART | aHR 2.02 (95% CI: 1.04–3.92) | ||||||||
| 4. | Nigusse et al., 2015 [16] | Retrospective follow up study | Hospital | Median 38 (IQR: 31.2–42) | 5 years | 480 | Overall TB incidence | 70 | |
| Overall TB incidence | 3.59 per 100 PY | ||||||||
| TB incidence among IPT | aHR = 0.49, 95% CI = 0.26–0.94 | ||||||||
| 5. | Ayele, 2015 [14] | Retrospective cohort study | Hospital | Range 15–99 years | 839 days | 1922 (374 received IPT) | Overall TB incidence | 258 | |
| Incidence of TB/death among IPT plus ART | HR = 0.35; 95% CI (0.16, 0.77) | ||||||||
| Incidence of TB/death among ART alone | HR = 1.22; 95% CI (0.45, 3.28) | ||||||||
| Incidence of TB/death among IPT plus ART | aHR = 0.40; 95% CI (0.18, 0.87) | ||||||||
| Incidence of TB among IPT plus ART | 5.20 per 100 PYs | ||||||||
| Incidence of TB among ART alone | 8.05 per 100 PYs | ||||||||
| 6. | Alemu et al., 2016 [21] | Retrospective cohort study | Hospitals (n = 2), Health centers (n = 6) |
Median (IQR) 6 (3.5–9.00) years |
N/A | 645 | Overall TB incidence | 79 | |
| Overall TB incidence | 4.2: 95% CI (3.4, 5.3) PY | ||||||||
| 7. | Teklay et al., 2016 [23] | Qualitative study | Hospitals (n = 11) | Mean (±SD) 30 (±6) years |
N/A | 50 health providers | Barriers | Isoniazid stock out | |
| Fear of creating isoniazid resistance Problems in patient acceptance Lack of commitment of health managers |
|||||||||
| 8. | Abossie et al., 2017 [15] | Hospital-based retrospective study | Hospital | Mean (±SD) 31.27 (+12.0) |
271 | Incidence of TB among IPT Plus ART | 12 (8.7%) | ||
| IPT 138 | No IPT 133 | Incidence of TB among ART alone | 37 (27.8%) | ||||||
| Incidence of TB among IPT Plus ART | RR 0.31 (95% CI 0.122, 0.49) | ||||||||
| 9. | Semu et al., 2017 [13] | Retrospective cohort | Public health institutions | Mean (±SD) 34.9 (±9.1) years |
5 years | 2524 patients | TB Incidence Rate among IPT | 0.21/100 PY | |
| TB-incidence Rate among at IPT completion | aIRR 0.037 (95% CI, 0.016–0.072) | ||||||||
| overall TB incidence | 6.7/100 PY | ||||||||
| TB incidence | 277 | ||||||||
| Incidence of TB among IPT-with-HAART | 0.42/100 PY | ||||||||
| Incidence of TB among IPT-with-HAART | aIRR = 0.063 (95% CI 0.035–0.104) | ||||||||
| Incidence of TB among alone HAART | 7.83 cases/100 PY | ||||||||
| 10. | Tiruneh et al., 2019 [18] | Retrospective cohort study | Hospital and health center | Mean (±SD) 33 years (±9) years |
Median 26 months | 600 | |||
| IPT 200 | No IPT 400 | Overall TB Incidence | 53 (8.8%) | ||||||
| Overall TB Incidence | 57 cases per 100 PY | ||||||||
| Incidence of TB among IPT group | 1.98 per 100 PY | ||||||||
| Incidence of TB among non-IPT group | 4.52 per 100 PY | ||||||||
| Incidence of TB among IPT group | aHR 0.45, 95% CI 0.219–0.920 | ||||||||
| Incidence of TB among IPT group | HR 0.397, 95% CI 0.203–0.774 | ||||||||
| 11. | Gebremariam et al., 2020 [20] | Retrospective cohort study | Hospitals (n = 2) | N/A | 5 years | 968 patients | Incidence of TB among ART plus IPT | 8 (0.5 cases/100 PY) | |
| IPT 484 | No IPT 484 | Incidence of TB among ART plus IPT | aHR 0.17; 95% CI 0.08–0.35 | ||||||
| Incidence of TB among ART alone | 49 (3 cases/100 PY) | ||||||||
| Deaths on ART plus IPT | 12 (0.5 cases/100 PYs) | ||||||||
| Deaths on ART alone | 35 (2.1 cases/100 PYs) | ||||||||
| Death reduction among ART plus IPT | aHR 0.48; 95% CI 0.24–0.97 | ||||||||
| 12. | Atey et al., 2020 [19] | Retrospective Cohort Study | Hospitals (n = 5) | N/A | N/A | 1863 | Incidence of TB among IPT Plus ART | 28 | |
| IPT 621 | No IPT 1242 | Incidence of TB among ART alone | 272 | ||||||
| Overall incidence | 300 | ||||||||
| Incidence rate of mortality among IPT Plus ART | 440 per 100,000 PYs | ||||||||
| Incidence rate of mortality among ART alone | 1490 per 100,000 PYs | ||||||||
| 13. | Legese et al., 2020 [22] | Institutional based cross-sectional | Hospital | Mean (±SD) 37.94 (±12.15) | 6 months | 372 (231 on IPT) | Overall incidence of TB among IPT group | 13 (3.5%) | |