TABLE 2.

IFN-γ restores the hepatic iNOS and ICAM-1 responses to LPS in DEM-treated CF1 mice^a

Antigen	Challenge	Positive cellsb
		KC (cells/HPF)	Hep (cells/HPF)	EC (intensity score)
TNF-α	LPS	<0.2	—	0
	LPS + IFN-γ	<0.2	—	0
iNOS	LPS	15.4 ± 2.3	0.6 ± 0.9	1
	LPS + IFN-γ	17.6 ± 2.3	28.8 ± 4.6∗	2
ICAM-1	LPS	4.0 ± 1.6	—	1
	LPS + IFN-γ	14.0 ± 4.1∗	—	2
F4/80	LPS	24.6 ± 4.3	—	0
	LPS + IFN-γ	26.4 ± 3.8	—	0

^aCF1 mice (five per group) were injected i.p. with DEM (5.3 mmol/kg) 2 h prior to challenge. Mice were challenged i.p. with either 100 μg of E. coli O111:B4 LPS or LPS plus 2 μg of recombinant IFN-γ. Liver samples were recovered 6 h later for immunohistology and read at ×400 magnification. 

^bSee Table 1, footnotes a and b. ∗,  these groups differed significantly from their controls (LPS only) (P < 0.01).