Table 1.

The role of the different specialized pro-resolving mediators in the resolution.

	Lipoxin	Resolvin E	Resolvin D	Protectin/ Neuroptotectin	Maresin
Precursor	AA	EPA	DHA	DHA	DHA
Receptors	ALX/FPR2 [48]	ChemR23 [49]	ALX/FPR2 GPR32 [50]	GPR37 [51]	RORa LGR6 [52]
Synthesis
Effects	1. ↑neutrophil apoptosis 2. ↓ cytokine production from neutrophil and T cell 3. ↓ macrophage apoptosis 4. ↑ macrophage efferocytosis 5. ↓ B cell Ab production	1. ↓ transendothelial and transepithelial migration of PMN 2. ↑ clearance of PMNs from apical mucosal surface [53] 3. ↓ growth of Gram- bacteria [54] 4. ↑ Macrophage efferocytosis [55] 5. ↓ DC IL12 production and migration towards T cell zone in spleen [49] 6. ↓ inflammatory pain [56]	1. ↓ neutrophil infiltration [57,58] 2. ↑ macrophage efferocytosis 3. ↓ T cell cytokine production and differentiation to Th1 and Th17 [50] 4. ↑ generation of Treg 5. ↓ inflammatory pain [56] 6. ↑ bacteria clearance [58,59]	PD: 1. ↓ PMN infiltration 2. ↓ T cell cytokine production 3. ↑ T cell apoptosis [60] NPD: ↓ RPE apoptosis from oxidative stress [61]	1. ↓ PMN infiltration 2. ↑ macrophage efferocytosis 3. ↑ M2 polarization 4. ↓ pain 5. ↑ tissue regeneration [62]