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Nonlytic doses of alpha-toxin productively activate the stably integrated proximal IL-8 promoter. ECV304 cells stably transfected with an IL-8–EGFP hybrid construct were treated with the depicted concentrations of alpha-toxin. FACScan analysis revealed toxin-dose-dependent increases in mean channel fluorescence, with maximum induction at 40 ng/ml. PMA (100 nM) served as a positive control. The experiment was repeated with virtually identical results.
