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. 2022 Dec 23;24(1):231. doi: 10.3390/ijms24010231

Figure 2.

Figure 2

Estrogen receptors and PPARγ are implicated in BPA- and TBT-induced α-cell apoptosis, respectively. (A) αTC1-9 cells were treated with vehicle (DMSO) or BPA (10 pM or 1 nM) in the absence (control) or presence of 1 µM ICI 182,780 for 24 h. (B) αTC1-9 cells were treated with vehicle (DMSO) or TBT (20 nM or 200 nM) in the absence (control) or presence of 100 nM T0070907 for 24 h. Apoptosis was evaluated using HO and PI staining. Data are shown as means ± SEM (n = 4 independent experiments, where each dot represents an independent experiment). ** p ≤ 0.01 and *** p ≤ 0.001 vs. its respective vehicle; ## p ≤ 0.01 and ### p ≤ 0.001 as indicated by bars. Two-way ANOVA.