Table 4.
Comparison of cytotoxicity (IC50, µM) of the tested compounds against MCF-7 cell line depending on the dicarboxylic linker and amine present in their structure.
| R2 |
|
|
|
|
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R1 | |||||||||||||||
|
2 (53.64) | 2b (19.27) | 2d (50.00) | 2a (29.79) | 2c (22.18) | ||||||||||
|
3 (38.22) | 3b (12.27) | 3d (34.05) | ||||||||||||
|
4 (43.93) | 4b (21.61) | 4d (50.00) | 4a (50.00) | |||||||||||
|
5 (12.27) | 5b (19.54) | |||||||||||||
| Betulin 1 (38.82) | |||||||||||||||
| Doxorubicin (0.08) | MCF-7 | ||||||||||||||
| Scale: | 1 | 2 | 5 | 10 | 15 | 25 | 35 | 38.82 | 45 | 50 | |||||
The color scheme visualizes active compounds in green and inactive ones in red. Color saturation corresponds to their degree of activity as indicated on the scale.