Table 5.
Comparison of cytotoxicity (IC50, µM) of the tested compounds against PC-3 cell line depending on the dicarboxylic linker and amine present in their structure.
| R2 |
|
|
|
|
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R1 | |||||||||||||||
|
2 (68.55) | 2b (17.86) | 2d (50.00) | 2a (4.47) | 2c (30.88) | ||||||||||
|
3 (34.42) | 3b (24.84) | 3d (46.11) | ||||||||||||
|
4 (36.19) | 4b (22.69) | 4d (50.00) | 3a (15.29) | |||||||||||
|
5 (19.77) | 5b (22.46) | |||||||||||||
| Betulin 1 (32.46) | |||||||||||||||
| Doxorubicin (0.43) | PC-3 | ||||||||||||||
| Scale: | 1 | 2 | 5 | 10 | 15 | 25 | 32.46 | 40 | 45 | 50 | |||||
The color scheme visualizes active compounds in green and inactive ones in red. Color saturation corresponds to their degree of activity as indicated on the scale.