Table 6.
The SI index = IC50 for normal cell line (BALB/3T3)/IC50 for respective cancerous cell line. A beneficial SI > 1.0 indicates a drug with efficacy against tumor cells greater than toxicity against normal cells.
| Compound | Cell Lines/Calculated Selectivity Index SI | |||
|---|---|---|---|---|
| MV4-11 | A549 | MCF-7 | PC-3 | |
| 2 | 2.3 | 1.5 | 1.0 | 0.8 |
| 2a | 1.5 | 0.2 | 0.1 | 0.7 |
| 2b | 6.4 | 3.1 | 1.3 | 1.4 |
| 2c | 5.7 | 4.7 | 1.5 | 1.1 |
| 2d | 15.8 | 1.6 | 1.0 | 1.0 |
| 3 | 1.9 | 1.3 | 1.0 | 1.1 |
| 3b | 2.8 | 3.3 | 2.0 | 1.0 |
| 3d | 11.8 | 7.4 | 1.5 | 1.1 |
| 4 | 1.6 | 1.2 | 0.9 | 1.0 |
| 4a | 1.2 | 0.2 | 0.1 | 0.3 |
| 4b | 5.9 | 4.3 | 1.7 | 1.6 |
| 4d | 7.1 | 1.2 | 1.0 | 1.0 |
| 5 | 4.7 | 4.8 | 1.9 | 1.2 |
| 5b | 2.9 | 1.6 | 1.0 | 0.9 |
| Betulin 1 | 1.8 | 2.0 | 0.8 | 1.0 |
| Doxorubicin | 18.0 | 4.5 | 2.3 | 0.4 |