Table 3.
IC50 values (μM) on inhibition of CYP3A4 cytochrome in cell in vitro model and cell-free assay.
| Cell Internalization of Rhodamine-123 in MCF-7/ADR 1 Cells Overexpressing P-gp | Ref | Human CYP3A4 Microsomes Expressed in Baculovirus 2-Insect Cell, Lineweaver–Burk Plot Analysis |
Ref | Residual Activity Compared to Control (6β-Hydroxylation of Testosterone-Marker Reaction of CYP3A4 Activity) |
Ref | ||
|---|---|---|---|---|---|---|---|
| Flavonols | Myricetin | 7.8 | [185] | 44.5 | [186] | 133 ± 35 | [187] |
| Quercetin | 1.97 | [182] | 22.1 | [186] | 126 ± 10 | [187] | |
| Kaempferol | 8.6 | [182] | 8.8 | [186] | 101 ± 14 | [187] | |
| Flavones | Apigenin | 1.8 | [182] | 0.4 | [186] | 24 ± 3 | [187] |
| Chrysin | nd | 0.9 | [186] | 17 ± 3 | [187] |
1 MCF-7/ADR—multidrug-resistant breast cancer cell model; 2 insect cells infected with a recombinant Baculovirus.