Table 4.

Cluster analysis revealed molecular alterations affecting invasive properties of PC driven by the Notch pathway. Blue color and “↓” indicates downregulation of the expression, red color and “↑” indicates upregulation of the expression, and NA indicates not available expression profile of a particular gene. All the resulting clusters are available in the Supplementary File S3.

		RNA-Seq						Microarrays
		Early			Late			Local			Regional
		≤55	60–70	70>	≤55	60–70	70>	≤55	60–70	70>	≤55	60–70	70>
ANK2	actin microfilaments	↓	↑	↑	↓	↑	↑	↓	↑	↓	↓	↑	↓
ANXA1		↓	↑	↑	↓	↓	↑	↓	↑	↓	↓	↑	↓
CALD1		↑	↓	↑	↓	↓	↑	↑	↑	↑	↓	↓	↓
CRB2		↑	↓	↑	↑	↓	↑	↑	↑	↓	↑	↑	↓
DST		↑	↓	↓	↓	↑	↑	↑	↑	↓	↓	↓	↑
FLNB		↑	↓	↓	↓	↑	↑	↑	↑	↓	↑	↑	↓
FN1		↑	↓	↓	↓	↑	↑	↓	↑	↓	↓	↑	↓
HIP1		↑	↑	↓	↑	↓	↓	↓	↓	↓	↑	↑	↑
MYO1D		↑	↓	↓	↓	↑	↑	↑	↑	↓	↑	↑	↓
MYO1F		↑	↑	↓	↑	↑	↑	↓	↓	↑	↓	↓	↑
MYO7A		↓	↓	↓	↓	↓	↑	↑	↓	↓	↑	↓	↑
CDH1	adhesion	↑	↓	↑	↓	↓	↑	↑	↓	↓	↑	↓	↓
CDH11		↓	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
CDH15		↓	↓	↑	↑	↑	↓	↑	↑	↓	↑	↓	↓
CDH22		↑	↑	↓	↓	↓	↓	NA
CDH26		↓	↑	↑	↓	↑	↑	↑	↑	↑	↑	↑	↓
CDH4		↓	↓	↑	↑	↑	↓	↓	↓	↓	↑	↑	↓
CDHR2		↑	↓	↑	↑	↓	↓	↓	↑	↓	↓	↓	↑
CDHR5		↑	↓	↓	↑	↓	↓	↑	↑	↓	↑	↑	↓
CLEC16A		↑	↓	↓	↓	↑	↑	↓	↑	↑	↑	↓	↓
CTNNA2		↓	↑	↑	↑	↑	↓	↑	↑	↑	↓	↑	↓
CTNNB1		↑	↓	↓	↓	↑	↑	↑	↑	↓	↓	↑	↑
GJA1		↓	↑	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
ICAM1		↑	↓	↓	↓	↓	↑	↓	↑	↓	↓	↑	↑
ICAM5		↑	↑	↓	↑	↑	↓	↓	↑	↓	↓	↑	↑
PLEC		↑	↓	↓	↓	↑	↑	↑	↑	↓	↑	↓	↓
TJP3		↑	↓	↓	↓	↓	↑	↓	↓	↑	↓	↓	↑
VEGFA	angiogenesis	↑	↓	↑	↓	↓	↑	↓	↓	↑	↓	↓	↑
VEGFC		↑	↓	↓	↑	↓	↓	↓	↑	↓	↑	↑	↑
BCL2	apoptosis	↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
CDK12	cell cycle	↑	↓	↓	↓	↓	↑	↑	↑	↓	↑	↑	↓
CDK19		↓	↓	↑	↓	↑	↑	↓	↓	↑	↑	↑	↓
CDKN1A		↑	↑	↓	↑	↓	↓	↓	↑	↓	↓	↑	↓
RB1		↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
TP63		↓	↑	↑	↓	↑	↑	↓	↓	↑	↓	↓	↑
LIN7A	cell polarity	↓	↑	↓	↑	↑	↓	↓	↓	↓	↓	↑	↑
COCH	ECM	↓	↓	↑	↓	↓	↑	↓	↓	↑	↓	↓	↑
COL14A1		↑	↓	↓	↓	↑	↑	↓	↑	↓	↓	↑	↓
COL4A4		↑	↓	↓	↓	↓	↑	↑	↑	↑	↓	↓	↓
COL6A2		↑	↑	↓	↓	↑	↑	↑	↑	↓	↓	↓	↓
COL8A1		↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
FBN1		↑	↓	↓	↓	↑	↑	↑	↑	↓	↑	↓	↑
FRAS1		↓	↑	↓	↓	↑	↑	↓	↑	↓	↑	↑	↑
GDF5		↑	↓	↑	↑	↓	↑	↑	↓	↑	↓	↑	↑
ITGA1		↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
ITGA10		↓	↑	↑	↓	↑	↑	↓	↓	↑	↓	↓	↑
ITGA6		↑	↓	↑	↓	↑	↑	↓	↓	↑	↓	↓	↑
ITGA8		↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
ITGAV		↑	↓	↓	↓	↑	↑	↓	↓	↑	↑	↓	↑
ITGB2		↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
ITGB8		↓	↑	↑	↓	↓	↑	↓	↓	↑	↑	↓	↓
LAMA1		↑	↓	↓	↑	↓	↓	↓	↓	↑	↑	↓	↑
LAMC2		↓	↑	↑	↓	↓	↑	↑	↑	↓	↑	↑	↓
LAMC3		↓	↑	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
LGALS3		↑	↓	↓	↓	↓	↓	↑	↑	↑	↑	↓	↓
MATN1		↑	↓	↑	↑	↓	↑	↓	↓	↓	↓	↑	↑
MATN2		↓	↑	↑	↓	↑	↑	↓	↓	↑	↑	↓	↑
MMP7		↑	↓	↓	↓	↑	↑	↓	↑	↑	↓	↓	↓
NPNT		↑	↓	↓	↑	↓	↓	↑	↑	↓	↓	↑	↓
NTN4		↓	↑	↑	↓	↑	↑	↓	↓	↑	↑	↓	↓
TNN		↓	↓	↓	↑	↓	↑	↑	↑	↓	↑	↑	↓
TNXB		↑	↓	↓	↓	↑	↑	NA
VTN		↓	↑	↓	↑	↑	↓	NA
MMP2		↓	↑	↓	↓	↑	↑	↓	↓	↓	↓	↓	↑
EGFR	EGFR signaling	↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
ERBB2		↓	↑	↑	↓	↑	↑	↑	↑	↓	↑	↑	↓
FCHO2	endocytosis	↑	↓	↑	↓	↑	↑	↓	↓	↑	↓	↓	↑
ESR1	estrogen	↑	↑	↓	↓	↑	↑	↑	↑	↓	↓	↓	↓
FGF1	FGF signaling	↑	↑	↓	↓	↑	↑	↓	↑	↓	↓	↓	↑
FGF12		↓	↑	↑	↓	↑	↑	↓	↓	↑	↑	↑	↓
FGF7		↑	↓	↓	↑	↓	↓	NA
FGF9		↑	↓	↓	↑	↓	↑	↓	↑	↑	↓	↑	↓
CREBBP	epigenetic regulators	↑	↓	↓	↓	↑	↑	↑	↑	↓	↓	↑	↓
DNMT1		↑	↓	↓	↑	↑	↑	↓	↓	↑	↓	↓	↑
EP300		↑	↓	↓	↓	↑	↑	↓	↓	↑	↑	↓	↑
HDAC1		↓	↓	↑	↓	↑	↑	↑	↑	↓	↑	↑	↓
HDAC6		↑	↓	↑	↓	↑	↑	↑	↑	↓	↓	↓	↓
FLG	intermediate filaments	↑	↓	↑	↓	↓	↑	↑	↑	↓	↑	↑	↓
VIM		↓	↑	↓	↓	↑	↑	↑	↑	↓	↓	↓	↑
MAP2	microtubules	↑	↓	↓	↓	↓	↓	↓	↓	↑	↓	↓	↑
MAP7		↓	↓	↑	↓	↑	↑	↓	↓	↑	↑	↓	↑
MAPRE3		↓	↓	↑	↓	↑	↑	↓	↑	↓	↓	↓	↑
MZT1		↓	↓	↑	↓	↑	↑	↓	↓	↑	↑	↑	↓
TUBA4A		↓	↑	↑	↓	↑	↑	↓	↓	↑	↓	↓	↑
TUBGCP4		↑	↓	↑	↓	↑	↑	NA
TUBGCP5		↑	↓	↑	↓	↓	↑	NA
DYNC1H1	molecular motors	↑	↓	↓	↓	↑	↑	↓	↑	↓	↓	↑	↓
KIF1B		↑	↓	↓	↓	↑	↑	↑	↑	↓	↑	↓	↑
KIF21A		↑	↓	↓	↓	↑	↑	↑	↑	↓	↑	↑	↓
KIF21B		↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
KIF26A		↑	↑	↓	↓	↑	↑	NA
KIF2A		↑	↓	↓	↓	↑	↑	NA
KIF3A		↑	↓	↓	↓	↑	↑	↓	↑	↓	↓	↑	↓
KIF3B		↑	↓	↓	↓	↓	↓	↓	↑	↓	↑	↑	↑
KIF5A		↓	↓	↓	↓	↓	↑	↓	↓	↓	↓	↑	↑
KIFAP3		↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
HES1	Notch	↓	↓	↑	↑	↑	↑	↓	↓	↑	↑	↓	↓
HES4		↓	↑	↓	↑	↑	↓	↓	↑	↓	↓	↑	↓
HES5		↓	↑	↑	↑	↑	↑	↓	↑	↑	↑	↓	↓
HEY1		↓	↑	↓	↑	↑	↓	↓	↑	↓	↓	↑	↑
HEY2		↓	↓	↓	↑	↑	↓	↑	↑	↓	↑	↑	↓
HEYL		↓	↑	↓	↑	↑	↑	↓	↑	↓	↑	↓	↑
NOTCH1		↑	↑	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
ERG	TF	↓	↓	↑	↓	↑	↑	↑	↑	↓	↑	↑	↓
GATA1		↑	↓	↓	↓	↓	↑	↑	↑	↓	↑	↑	↓
MYC		↑	↓	↓	↑	↑	↓	↓	↑	↑	↓	↑	↓
TCF4		↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
TFAP2A		↓	↑	↑	↓	↑	↑	↑	↓	↓	↑	↑	↓
SNAI2	TF/EMT	↓	↑	↑	↓	↑	↑	↓	↓	↑	↓	↓	↑
TWIST1		↓	↑	↓	↑	↑	↓	↑	↓	↓	↑	↑	↑
ZEB2		↑	↓	↓	↓	↑	↑	↓	↓	↑	↓	↓	↑
HIF1A	TF/hypoxia	↑	↓	↓	↓	↑	↑	↓	↑	↓	↓	↑	↓
SMAD3	TGFβ signaling/EMT	↓	↑	↓	↓	↑	↑	↑	↑	↑	↓	↓	↓