Figure 10.

Sensitization in biological models. (A) An example of sensitization in a potential memory model built from [75] that passed the pretest. (B) On the left, the effects of a single stimulation—an upregulation of the UCS results in an upregulation of R. On the right, an example of sensitization. Progressive stimulation (upregulation, red shaded area) of UCS results in less and less response from R (upregulation to upregulation). (C) Distribution of pharmacoresistance across all biological models and random networks. The x axis is measured as the percentage of memory models for a given biological model that show sensitization. We performed a Wilcoxon rank sum test applicable to un-equal samples to test the similarity of the distributions and they are significantly different (p = 5.13 × 10⁻⁷⁰).