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Asbestosis influences macrophage activity which is important for eliminating cellular debris, and acts on ATII cells by activating the mitochondrial and p53 death pathways. Asbestos catalyzes lipid peroxidation by decreasing PLC, which decreases phosphatidylinositol, phosphatidylglycerol, and phosphatidylserine synthesis. Another important event is the alteration of CC-16 with fibroblast chemotaxis activity, increased Sp-A and PLA2. Figure created in BioRender.com.
