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. 2022 Dec 29;24(1):596. doi: 10.3390/ijms24010596

Figure 9.

Figure 9

Effect of 4-DAMP treatment on the expression of phosphokinases in vivo. Mouse Phospho-RTK Array measuring phospho-RTK activity in tumors from mice with CT-26-induced CRC treated with DMSO (A) and 4-DAMP (B). TGF-β in tumor samples from mice bearing CT-26 cell-induced tumors treated with DMSO (C–C’’) and 4-DAMP (D–D’’). Tumors were labeled with the nuclei marker DAPI (blue; C,D), TGF-β (green; C’,D’), and all markers merged (C’’,D’’). The scale bar represents 50 µm. Bar graphs displaying the mean fluorescence level of TGF-β (E) in tumor samples from DMSO-treated and 4-DAMP-treated mice. Data presented as mean ± SEM, n = 8 per group. Student’s t-test, **** p < 0.0001.