Figure 2.

(A) Comparison of SOD1 mutant mouse populations showing an inverse correlation between the average age at onset and the average incidence in the same population. (B) The application of the Armitage and Doll model suggests that the lower the number of steps towards onset, the earlier the average age at onset of animals. (C) Linear regression and correlation of the actual incidence values extracted from primary studies and those predicted by the mathematical model. The strong correlation suggests the high predictability of the model.