Table 5.
Analysis of the localization domains of PSPs.
| PSP | Sequence Name |
Length | Protein Mm (Da) |
SignalP-6.0 * | TargetP-2.0 * | DeepTMHMM Server | Experimental Data (For Mammalian PSPs Only) |
|
|---|---|---|---|---|---|---|---|---|
| Signal Peptide | Signal Peptide | Mitochondrial Transit Peptide |
TMhelix | |||||
| POP | POP_Hs | 710 | 80,700 | Cytoplasm [28] | ||||
| POP_Tc | 704 | 80,212 | ||||||
| POP_Tm | 705 | 80,116 | 1–21 (0.90/0.79) | |||||
| DPP 4 | DPP4_Hs | 766 | 88,279 | 1–22 (0.78/0.40) | 7–27 | Membrane [30,31], soluble [47] | ||
| DPP4.1_Tc | 767 | 87,333 | 1–19 (0.99/0.98) | 1–19 (0.99/0.73) | ||||
| DPP4.2_Tc | 821 | 92,585 | 34–54 | |||||
| DPP4.1_Tm | 768 | 86,576 | 1–19 (0.99/0.98) | 1–19 (0.99/0.78) | ||||
| DPP4.2_Tm | 803 | 90,278 | 34–54 | |||||
| DPP 8 | DPP8_Hs | 898 | 103,358 | Cytoplasm [26,33] | ||||
| DPP8_Tc | 825 | 95,048 | ||||||
| DPP8_Tm | 825 | 94,870 | ||||||
| DPP 10 | DPP10_Hs | 796 | 90,888 | 35–55 | Extracellular membrane [26,35] | |||
| DPP10.1_Tc | 835 | 96,053 | 37–58 | |||||
| DPP10.2_Tc | 845 | 95,598 | 46–66 | |||||
| DPP10.3_Tc | 858 | 97,129 | 25–45 | |||||
| DPP10.1_Tm | 843 | 96,808 | 45–66 | |||||
| DPP10.2_Tm | 882 | 99,854 | 79–100 | |||||
| PRCP | PRCP_Hs | 496 | 55,800 | 1–21 (0.99/0.98) | 1–21 (0.99/0.48) | Lysosome [36,37,38] | ||
| PRCP.1_Tc | 488 | 55,131 | 1–16 (0.99/0.98) | 1–16 (0.92/0.88) | ||||
| PRCP.2_Tc | 478 | 53,843 | 1–17 (0.99/0.98) | 1–17 (0.99/0.96) | ||||
| PRCP_Tm | 488 | 55,105 | 1–15 (0.99/0.98) | 1–15 (0.99/0.87) | ||||
| APP 1 | APP1_Hs | 623 | 69,918 | Cytoplasm [43] | ||||
| APP1.1_Tc | 615 | 69,050 | ||||||
| APP1.2_Tc | 690 | 79,273 | 1–13 (0.99/0.98) | 1–14 (0.89/0.37) | ||||
| APP1_Tm | partial | partial | ||||||
| APP 2 | APP2_Hs | 674 | 75,625 | 1–21 (0.99/0.98) | 1–23 (0.99/0.54) | Plasma membrane [42] | ||
| APP2_Tm | 709 | 81,041 | 1–25 (0.83/0.81) | 1–25 (0.99/0.97) | ||||
| APP 3 | APP3_Hs | 507 | 57,034 | 1–31 (0.89/0.72) | Mitochondrion [44] | |||
| APP3_Tc | 503 | 57,581 | 1–22 (0.58/0.43) | |||||
| APP3_Tm | 504 | 57,356 | –(0.32) | |||||
| XPD | XPD_Hs | 493 | 54,548 | - | ||||
| XPD_Tc | 487 | 54,319 | ||||||
| XPD_Tm | 489 | 54,168 | ||||||
| LAP | LAP_Hs | 519 | 56,166 | 1–27 (0.95/0.60) | Microsomes, cytoplasm [45] | |||
| LAP.1_Tc | 447 | 48,087 | ||||||
| LAP.2_Tc | 530 | 58,105 | 1–26 (0.94/0.71) | |||||
| LAP.3_Tc | 534 | 58,852 | 1–21 (0.93/0.81) | |||||
| LAP_Tm | 513 | 55,124 | 1–24 (0.91/0.31) | |||||
| CND | CND_Hs | 475 | 52,878 | Cytoplasm [46] | ||||
| CND_Tc | 478 | 53,583 | ||||||
| CND_Tm | 478 | 53,794 | ||||||
* After the cleavage site position of the signal peptide or mitochondrial transit peptide in brackets, the number before the slash is the likelihood of the specified localization domain appearing and the number after the slash is the probability of cleavage at the indicated position.