Table 1.

Multiple myeloma diagnostic criteria

Clonal bone marrow plasma cells	≥10%
OR
Biopsy-proven plasmacytoma
AND
“CRAB”	Hypercalcemia: Serum calcium >11  mg/dL or >1  mg/dL above ULN
	Renal insufficiency: Serum creatinine >2  mg/dL or CrCl <40  mL/min
	Anemia: Hemoglobin <10  g/dL or >2  g/dL below LLN
	Bone lesions: ≥1 osteolytic lesion (on WBLDCT or PET scan)
OR
“SLiM” criteria	≥60% clonal bone marrow plasma cells
	Involved to uninvolved FLC ratio ≥100 and involved FLC ≥10  mg/dL
	>1 focal lesion on MRI ≥5  mm in size

FLC, free light chain; MRI, magnetic resonance imaging; PET, positron emission topography; WBLDCT, whole-body low-dose computed tomography.