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. 2022 Dec 27;24(1):442. doi: 10.3390/ijms24010442

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Viability of SH-SY5Y cells pre-treated with VANL-100, NAR, ALA, or NAR + ALA for 24 h followed by 24-h treatment with Aβ_25–35. Cell viability, represented as % control, is shown on the y-axis, and antioxidant concentrations are displayed on the x-axis. The bars represent the mean ± SEM of six independent experiments. (A,B) VANL-100 + non-fibril and fibril Aβ_25–35, respectively. (C,D) NAR + non-fibril and fibril Aβ_25–35, respectively. (E,F) ALA + non-fibril and fibril Aβ_25–35, respectively. (G,H) NAR + ALA + non-fibril and fibril Aβ_25–35, respectively. Statistical significance vs. Aβ was assessed using one-way ANOVA. * p <0.05; ** p< 0.01; *** p < 0.001; **** p < 0.0001.