Figure 5.

Schematic representation of anticancer activity through decreased BCSC. Tumor suppressive role of PTEN, whose gain in responding to UA decreases the fraction of CSC by downregulating the expression of AGO2 to inactivate the FAK/PI3K/Akt/mTOR and c-Myc signaling pathway. The model also suggests that UA decreased the AGO2-mediated biogenesis of miR-9 and -221 that contribute to the reduction in slug and vimentin, leading to the inhibition of breast cancer invasion and migration during EMT.