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Effectors of integrin-mediated recognition on Col-I. Signaling activated by the recognition of Col-I substrates by integrins and DDR, as well as stimulation of soluble factors such as TGF-β, regulate cell behavior in concert. In addition, integrin-mediated signals are influenced by the factors on the gel-forming state of Col-I, such as the arrangement of cell recognition sites, surface topography, and stiffness.
