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. 2022 Dec 21;24(1):142. doi: 10.3390/ijms24010142

Table 2.

Effects of L. Bacillus against different diseases.

Serial Number Specie of Lactobacillus Mechanism of Action Result Reference
1 Lactobacillus Plantarum HY7714

  • Reduce inflammation by regulating the expression of matrix metallopeptidases (MMP-9 and MMP-2), calprotectin, and zonulin in plasma.

  • Enhanced IGFBP5, SERPINE1, EFEMP1, COL6A3, and SEMA3B

  • Downregulation of MT2A, MT1E, MT1X, MT1G, and MT1F.

 These results enforce that via modulating gut microbiota probiotics are beneficial for skin health. [66]
2 Lactobacillus fermentum KBL375

  • Mast cells and eosinophils ↓

  • Th2 based cytokines ↓

  • Anti-inflammatory cytokines ↑

 Useful for the treatment of atopic dermatitis via immune and metabolic modifications. [67]
3 lipoteichoic acids obtained from Lactobacillus Plantarum along with Staphylococcus aureus

  • CD55 and CD59 production ↑

  • Downregulation of MACs

  • Induced Th1-mediated immune response

 This combination could efficaciously alleviate atopic dermatitis symptoms. [68]
4 Lactobacillus salivarius LA307 along with Lactobacillus rhamnosus LA305

  • Reduced levels of serum pro-inflammatory cytokines IL-1β, IL-6, TNF-α, IL-17, IL-22

  • Increased levels of anti-inflammatory cytokine IL-4 and IL-10

 The study suggested that probiotic is beneficial for skin elasticity and is also effective against atopic dermatitis. [69]
5 Probiotic Lactobacillus sakei proBio-65

  • Decreased levels of pro-inflammatory cytokines such as IL-17A, IL-19, and IL-23 obtained through mRNA expression analysis

 The current study revealed that this extract could be a novel treatment for treating psoriasis and an alternative to other drugs that result in several side effects. [70]
6 Lactobacillus acidophilus

  • Transforming growth factor-β ↑

  • IL-12 ↑

  • Suppresses type-2-helper-T cell-dominant inflammation

 This study shows a significant reduction in symptoms of eczema and atopic dermatitis. [71]
7 Lactobacillus casei

  • Reduced concentration of CD8+ CTL

  • Enhanced level of CD4+ regulatory T cells

 Oral administration of L. casei may ameliorate skin inflammation by regulating the size of CD8 cell pool. [72]