Table 1.
Case: clinicopathologic characteristics
| Lab | Unit | Range | Bone marrow | |
|---|---|---|---|---|
| Hemoglobin | 8.1 g/dL | (14.0-17.5) | Morphology | Normal cellular marrow with 20.3% blasts and with dysplastic erythropoiesis (megaloblastosis, abnormalities of the nucleus) and absent megakaryocytes |
| MCV | 96 fL | (80-100) | ||
| Platelets | 8 × 109/L | (150-350) | ||
| WBC count | 1.06 × 109/L | (3.5-10.0) | ||
| Neutrophils | 0.08 × 109/L | Flow cytometry | Immature myeloid population with a phenotype consistent with AML (20%) | |
| Lymphocytes | 0.85 × 109/L | |||
| Eosinophils | 0.02 × 109/L | NGS | TP53 mutation, VAF 69% | |
| Monocytes | 0.08 × 109/L | Karyotype | Monosomal karyotype 47 ~ 50,Y,add(X)(p),add(3)(q),del(5)(q),+6,+8,del(11)(q),-13,-16,add(17)(p11)[19]/46,XY[1] | |
| Blasts | 0.03 × 109/L | |||
| LDH | 340 U/L | (<248) | ||
LDH, lactase dehydrogenase; MCV, mean corpuscular volume; NGS, next generation sequencing; WBC, white blood count.