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(Top panel) Schematic representation of membrane-bound structure (1xq8.pdb) of αSyn; NT is the N-terminal domain 1-60, NAC refers to the Non-Amyloid Component 61-95, and CT corresponds to the C-terminal region 96-140. (Bottom panel) Domain architecture, amino acid sequence and proteolytic cleavage sites (↑) of αSyn by different proteases, i.e., calpain-1 (C), cathepsin (Cat) B, D and L, matrix metallo-proteinase-3 (MMP3), neurosin (N), and plasmin (P).
