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. 2022 Dec 24;24(1):299. doi: 10.3390/ijms24010299

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mechanism of action underlying the effect of isorhamnetin on adipogenesis. αPR: progesterone receptor α; ACC: acetyl coA carboxylase; AP2: adipose fatty acid-binding protein 2; C/ebp: CCAAT-enhancer-binding protein; DKK: Dickkopf; FZD: frizzled class receptor; GLUT4: glucose transporter member 4; GSK-3β: glycogen synthase kinase-3 beta; PPARγ: peroxisome proliferator activated receptor γ; RXRα: retinoid X receptor alpha; SFRP: secreted frizzled related protein; SREBP1c: sterol regulatory element-binding protein 1c. Green arrows: upregulation by isorhamnetin; red arrows: downregulation by isorhamnetin.