Table 4.
Correlation between polyamine levels and clinical-pathological features in patients with colorectal carcinoma.
| Polyamines | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AGMATINE | ARGININE | CADAVERINE | LYSINE | ORNITHINE | PUTRESCINE | ACETYL-PUTRESCINE | SPERMIDINE | ACETYL-SPERMIDINE | SPERMINE | ACETYL-SPERMINE | |||||||||||||
| Media ± SD | p Value | Media ± SD | p Value | Media ± SD | p Value | Median (IQR) | p Value | Median (IQR) | p Value | Median (IQR) | p Value | Median (IQR) | p Value | Median (IQR) | p Value | Median (IQR) | p Value | Media ± SD | p Value | Media ± SD | p Value | ||
| Gender | |||||||||||||||||||||||
| Female. n (%) | 17 (34.0) | 24.0 ± 2.4 | 0.819 | 7.6 ± 0.8 | 0.942 | 13.9 ± 1.7 | 0.419 | 1.1 (1.0–1.1) | 0.728 | 2.6 (2.6–2.6) | 0.943 | 17.8 (17.1–18.8) | 0.384 | 297.3 (287.7–306.2) | 0.029 | 126.8 (121.2–134.6) | 0.320 | 9.38 (8.6–11.4) | 0.260 | 6.7 ± 1.9 | 0.388 | 14.8 ± 1.6 | 0.562 |
| Male. n (%) | 33 (66.0) | 24.2 ± 2.7 | 7.6 ± 0.5 | 14.3 ± 1.7 | 1.1 (1.0–1.1) | 2.6 (2.6–2.7) | 17.6 (17.1–18.8) | 285.6 (278.6–295.6) | 129.2 (126.4–134.3) | 10.6 (9.4–15.2) | 7.2 ± 1.7 | 14.6 ± 1.1 | |||||||||||
| Age at diagnosis | |||||||||||||||||||||||
| < 65 years. n (%) | 19 (38.0) | 23.5 ± 2.2 | 0.194 | 7.7 ± 0.7 | 0.645 | 14.1 ± 1.7 | 0.687 | 1.1 (1.0–1.1) | 0.764 | 2.6 (2.6–2.6) | 0.45 | 17.4 (16.8–18.1) | 0.105 | 286.7 (280.1–304.0) | 0.49 | 130.8 (123.1–135.5) | 0.834 | 10.1 (8.6–11.8) | 0.749 | 7.2 ± 1.8 | 0.573 | 14.8 ± 1.7 | 0.619 |
| ≥ 65 years. n (%) | 31 (62.0) | 24.5 ± 2.8 | 7.6 ± 0.6 | 14.3 ±1.7 | 1.1 (1.0–1.1) | 2.6 (2.6–2.7) | 17.9 (17.4–18.9) | 290.2 (278.4–299.0) | 129.1 (125.3–133.7) | 10.4 (9.2–11.8) | 6.9 ± 1.8 | 14.6 ± 1.0 | |||||||||||
| Localization | |||||||||||||||||||||||
| Left. n (%) | 35 (70.0) | 23.7 ± 2.5 | 0.044 | 7.7 ± 0.6 | 0.469 | 14.2 ± 1.8 | 0.808 | 1.1 (1.0–1.1) | 0.428 | 2.6 (2.6–2.6) | 0.893 | 17.6 (17.0–18.4) | 0.696 | 288.5 (279.4–301.0) | 0.903 | 129.2 (125.0–134.6) | 0.942 | 10.2 (9.0–11.8) | 0.329 | 7.1 ± 1.7 | 0.856 | 14.7 ± 1.4 | 0.945 |
| Right. n (%) | 12 (24.0) | 25.5 ± 2.7 | 7.5 ± 0.6 | 14.1 ± 1.1 | 1.1 (1.0–1.2) | 2.6 (2.4–2.7) | 18.0 (16.9–19.1) | 288.5 (279.5–301.3) | 129.6 (124.0–134.4) | 11.0 (9.9–12.0) | 7.2 ± 2.1 | 14.7 ± 1.0 | |||||||||||
| Histologic grade | |||||||||||||||||||||||
| G1-G2. n (%) | 39 (76.5) | 24.1 ± 2.8 | 0.776 | 7.6 ± 0.6 | 0.727 | 14.3 ± 1.5 | 0.754 | 1.1 (1.0–1.1) | 0.188 | 2.6 (2.6–2.7) | 0.047 | 17.8 (17.0–18.4) | 0.620 | 286.7 (278.9–299.5) | 0.234 | 129.8 (126.3–134.3) | 0.096 | 10.3 (9.0–11.8) | 0.551 | 7.1 ± 1.7 | 0.727 | 14.6 ± 1.3 | 0.448 |
| G3. n (%) | 10 (19.6) | 24.3 ± 2.1 | 7.5 ± 0.8 | 14.1 ± 2.3 | 1.1 (1.1–1.2) | 2.6 (2.4–2.6) | 18.1 (17.1–19.6) | 295.4 (285.2–310.8) | 124.1 (122.7–130.0) | 10.9 (8.9–12.0) | 6.9 ± 2.0 | 14.9 ± 1.2 | |||||||||||
| Tumor stage | |||||||||||||||||||||||
| 0-I-II. n (%) | 24 (47.1) | 24.7 ± 2.5 | 0.19 | 7.7 ± 0.5 | 0.238 | 14.3 ± 1.5 | 0.846 | 1.1 (1.0–1.1) | 0.828 | 2.6 (2.6–2.7) | 0.261 | 17.9 (17.4–18.8) | 0.332 | 291.2 (279.5–299.5) | 0.837 | 129.2 (125.0–133.5) | 0.901 | 9.8 (9.0–11.8) | 0.869 | 7.0 ± 1.7 | 0.893 | 15.1 ± 1.3 | 0.009 |
| III-IV. n (%) | 24 (47.1) | 23.6 ± 2.8 | 7.5 ± 0.7 | 14.2 ± 1.9 | 1.1 (1.0–1.1) | 2.6 (2.6–2.6) | 17.7 (16.8–18.7) | 291.8 (279.3–304.0) | 129.4 (123.6–134.5) | 10.3 (8.7–11.6) | 7.0 ± 1.8 | 14.2 ± 1.1 | |||||||||||
SD = standard deviation; IQR = interquartile range.