Figure 7.

Association of CSF AD biomarkers – Aβ_1–42/p-tau₁₈₁ ratio (A), p-tau₁₉₉ (B), p-tau₂₃₁ (C), VILIP-1 (D), S100B (E), NFL (F), PAPP-A (G), and albumin (H) with plasma macro- and microelement groups revealed by the PCA. Effect sizes and 95% confidence intervals are given by linear regression analysis (statistically significant factors are considered those represented with horizontal lines that do not intersect with the vertical line at 0). Factor 1; plasma Ca, Co, Cu, Mg, Mn, Na, P, S, Se, Tl, and Zn; Factor 2; plasma B, Cd, Li, Mo, and Pb; Factor 3; plasma As and Hg; Factor 4; plasma Ni; Factor 5; plasma Sr; Factor 6; plasma Fe.