Table 3.
Score | Lymphoid Infiltrate | LEL | Stromal Changes | Clinical Significance |
---|---|---|---|---|
Complete histologic response (ChR) | Absent or scattered plasma cells and small lymphoid cells in LP | Absent | Normal or empty LP and/or fibrosis | Complete remission |
Probable minimal residual disease (pMRD) | Aggregates of lymphoid cells or lymphoid nodules in LP/MM and/or SM | Absent | Empty LP and/or fibrosis | Complete remission |
Responding residual disease (rRD) | Dense, diffuse, or nodular, extending around glands in LP | Focal or absent | Focal empty LP and/or absent | Partial remission |
No change (NC) | Dense, diffuse, or nodular | Present, may be absent | No changes | Stable or progressive disease |
GELA: Groupe d’Etude des Lymphomes de l’Adulte; LEL: lymphoepithelial lesion; LP: lamina propria; MALT: mucosa-associated lymphoid tissue; MM: muscularis mucosae; SM: submucosa.