Table 2.

Hazard Associated with each Standard Deviation Change in Peak Vo₂.

	Model 1 Univariate		Model 2 Demographics		Model 3 Clinical Covariates
	HR § (95% CI)	p-Value	HR (95% CI)	p-Value	HR (95% CI)	p-Value
Peak Oxygen Consumption Absolute Peak Vo2 (SD ± 414 mL O2/min)	0.75 (0.60, 0.93)	0.010	0.60 (0.46, 0.78)	0.000	0.62 (0.47, 0.81)	0.001
% Predicted Peak Vo2 (SD ± 14%)	0.66 (0.53, 0.84)	0.001	0.63 (0.50, 0.81)	0.000	0.68 (0.53, 0.87)	0.002
Peak Vo2, body mass (SD ± 4 mL O2/min/kg body mass)	0.69 (0.55, 0.87)	0.002	0.66 (0.52, 0.83)	0.000	0.72 (0.56, 0.91)	0.007
Peak Vo2, lean (SD ± 6 mL/min/kg lean mass)	0.62 (0.49, 0.78)	0.000	0.63 (0.50, 0.79)	0.000	0.68 (0.53, 0.86)	0.002
O2 Pulse (SD ± 3 mL O2/beat)	0.81 (0.65, 0.99)	0.043	0.66 (0.52, 0.85)	0.001	0.66 (0.51, 0.85)	0.002

Higher Peak Vo₂ is associated with a decreased hazard of death or retransplantation. Model 1—unadjusted Cox proportional hazard model. Model 2—adjusted for age, race/ethnicity, sex, and days from transplant to CPET. Model 3—adjusted for Model 2 variables plus pulmonary vascular resistance, type 2 diabetes, ischemic cardiomyopathy, peripheral-vascular disease, chronic obstructive pulmonary disease, and hemoglobin. Hazard ratios (HR) are for a one standard deviation (SD) change in each metric. Acronyms: Vo₂, oxygen consumption.