TABLE 1.
Meningeal genes differentially regulated following meningococcal challenge for 4 h
| Genes and products | Expression levels
|
|
|---|---|---|
| Fold increase | Fold decrease | |
| Cytokine, chemokine, and adhesion molecule genes | ||
| IL-6a | 4.0 | |
| IL-8a | +b | |
| ICAM-1a | 10.0 | |
| LIFa | 12.0 | |
| MIP-2αa | 113 | |
| MCP-1a | 11.0 | |
| Opnc | 5.0 | |
| TNF-αa | 350 | |
| VCAM-1a | 2.9 | |
| VEGFa | 4.9 | |
| Apoptosis-related genes | ||
| BB2-bombesin receptorc | + | |
| BDNFa | 6.0 | |
| Caspase 10a | 6.0 | |
| IEX-1L anti-death proteina | + | |
| IRF-1a | 3.5 | |
| Opnc | 5.0 | |
| Other regulated genes | ||
| Bcl-3a | 6.4 | |
| B94 proteina | 2.5 | |
| Basic helix-loop-helix protein DEC1c | 1.9 | |
| E16 amino acid transportera | 3.2 | |
| Erythroblastosis virus oncoprotein homolog ETS-1; p54ac | 2.8 | |
| Fos-related antigen (Fra-1)a | 4.8 | |
| 40S rRNAa | 5.0 | |
| gadd45a | 5.3 | |
| Glucose transporter 1a | 2.3 | |
| Guanine nucleotide binding proteina | + | |
| Human immunodeficiency virus enhancer binding protein 2a | 3.8 | |
| Insulin-like growth factor binding protein 1a | 1.5 | |
| NOR-1c | + | |
| Placenta growth factors 1 and 2a | 1.6 | |
| Proto-oncoprotein c-Jun; transcription factor AP-1a | 2.0 | |
| RNA polymerase II subunitd | 1.8 | |
| Stanniocalcinc | 3.4 | |
| Sterol-C5 desaturasec | 10.0 | |
| Transforming growth factor-β inducible early genec | 4.2 | |
| TG-interacting factorc | 1.6 | |
| Transcription factor AP-2a | 8.4 | |
| Vav-2 proteinc | 7.5 | |
a
Atlas array 1.2 I.
b
+, not detected on control arrays, represented by array A (Fig. 1).
c
Atlas array 1.2 II.
d
Atlas array 1.2 III.