∆ψm	Mitochondrial membrane potential
aa	Amino acid(s)
AAV	Adeno-associated virus
ABCA1	ATP-binding cassette transporter A1
AD	Alzheimer’s disease
ADNP	Activity Dependent Neuroprotector Homeobox
APOE	Apolipoprotein E
ApoE4	Apolipoprotein E4
APP	Amyloid precursor protein
APP/PS1	Mice expressing APP-Swedish and PSEN1-dE9 mutations
ASO	Antisense oligonucleotides
Aβ	Amyloid-β peptide
Aβ40	Aβ peptide with 40 amino acids
Aβ42	Aβ peptide with 42 amino acids
AβO	Aβ1–42 oligomers
BDNF	Brain-derived neurotrophic factor
BiP	Binding immunoglobulin protein
C-terminal	Carboxyl-terminal
CCCP	Carboxyl cyanide m-chlorophenyl hydrazone
COMMD6	COMM Domain Containing 6
COX	Cytochrome c oxidase (or Complex IV or CxIV)
CSF	Cerebrospinal fluid
Drp1	Dynamin-like protein 1
EOAD	Early-onset Alzheimer’s disease
ER	Endoplasmic reticulum
FADH2	Flavin adenine dinucleotide, reduced form
Fis1	Mitochondrial fission protein-1
GSK3β	Glycogen synthase kinase-3 β
HDAC	Histone deacetylase
IL-1β	Interleukin-1β
IL-6	Interleukin-6
IP3	Inositol 1,4,5-trisphosphate
IP3R	Inositol 1,4,5-trisphosphate receptor
iPSC	Induced pluripotent stem cells
KI	Knock-in
LDL	Low density lipoprotein
LDLR	Low density lipoprotein receptor
LOAD	Late-onset Alzheimer’s disease
LRP1	LDL receptor-related protein-1
MADD	MAPK Activating Death Domain
MAM	Mitochondria-ER-associated membranes
MAPK	Mitogen-activated protein kinase
MCI	Mild cognitive impairment
mEPSC	Mini-excitatory postsynaptic current
MFN1/2	Mitofusin 1/2
mPTP	Mitochondrial permeability transition pore
MRI	Magnetic resonance imaging
mRNA	messenger RNA
mtDNA	mitochondrial DNA
N-terminal	Amino-terminal
N2a	Neuro-2a cell line
NADH	Nicotinamide adenine dinucleotide, reduced form
NFTs	Neurofibrillary tangles
NFκB	Nuclear factor-κB
NMDAR	N-methyl-D-aspartate receptor
NRF1/2	Nuclear Respiratory Factor 1/2
NSE	Neuron-specific enolase
OCR	Oxygen consumption rate
OPA1	Optic atrophy 1 protein
P-tau	Hyperphosphorylated tau protein
PET	Positron emission tomography
PP2A	Protein phosphatase 2A
PPP2R5E	Protein phosphatase 2, regulatory subunit B’, epsilon isoform
PSEN1 (or PS1)	Presenilin 1
PSEN2	Presenilin 2
ROS	Reactive oxygen species
TNFα	Tumor necrosis factor α
TR	Target replacement
VDAC	Voltage-dependent anion-selective channel