Table 1.
Key sociodemographic and clinical characteristics of vaccinated and control groups
| Vaccinated cohort | Unvaccinated controls | |
|---|---|---|
| Number of pregnancies reaching ≥ 12 weeks gestation | 6623 | 19,981 |
| Total babies resulting from these pregnancies [live births] | 6731 [6445] | 20,193 [19,365] |
| Median maternal age (min-max) [standard deviation] | 32 (16–46) [5.1] | 32 (16–47) [4.9] |
| Maternal deprivation (SIMD quintile)* | ||
| 1 (most deprived) | 1119 (16.6%) | 4340 (21.5%) |
| 2 | 1181 (17.5%) | 3895 (19.3%) |
| 3 | 1269 (18.9%) | 3663 (18.1%) |
| 4 | 1580 (23.5%) | 4467 (22.1%) |
| 5 (least deprived) | 1582 (23.5%) | 3811 (18.9%) |
| Unknown | 0 | 17 (0.1%) |
| Maternal ethnicity | ||
| White | 6023 (89.5%) | 16,949 (83.9%) |
| South Asian | 243 (3.6%) | 735 (3.6%) |
| Black/Caribbean /African | 85 (1.3%) | 435 (2.2%) |
| Other/mixed ethnicity | 229 (3.4%) | 845 (4.2%) |
| Unknown | 151 (2.2%) | 1229 (6.1%) |
| Maternal urban/rural status | ||
| Large urban areas | 2474 (36.8%) | 7498 (37.1%) |
| Other urban areas | 2240 (33.3%) | 7082 (35.1%) |
| Accessible small towns | 563 (8.4%) | 1549 (7.7%) |
| Remote small towns | 226 (3.4%) | 585 (2.9%) |
| Accessible rural areas | 818 (12.2%) | 2349 (11.6%) |
| Remote rural areas | 343 (5.1%) | 918 (4.5%) |
| Unknown | 67 (1.0%) | 212 (1.0%) |
| Maternal clinical vulnerability** | ||
| Not vulnerable | 4803 (71.4%) | 14,871 (73.6%) |
| Vulnerable | 1822 (27.1%) | 5156 (25.5%) |
| Extremely vulnerable | 106 (1.6%) | 166 (0.8%) |
| Maternal diabetes | ||
| No - assumed & confirmed | 6133 (91.1%) | 18,536 (91.8%) |
| Pre-existing diabetes | 114 (1.7%) | 155 (0.8%) |
| Gestational Diabetes/onset unknown | 484 (7.2%) | 1502 (7.4%) |
| Maternal smoking status | ||
| Non-smoker | 4885 (72.6%) | 13,857 (68.6%) |
| Ex-smoker | 1292 (19.2%) | 4033 (20.0%) |
| Smoker | 523 (7.8%) | 2227 (11.0%) |
| Unknown | 31 (0.5%) | 76 (0.4%) |
| Maternal body mass index | ||
| Underweight | 97 (1.4%) | 406 (2.0%) |
| Healthy weight | 2354 (35.0%) | 7273 (36.0%) |
| Overweight | 1978 (29.4%) | 6207 (30.7%) |
| Obese/severely obese | 2056 (30.5%) | 5609 (27.8%) |
| Unknown | 246 (3.7%) | 698 (3.5%) |
| Baby from singleton or multiple pregnancy | ||
| Singleton | 6517 (96.8%) | 19,579 (97.0%) |
| Multiple | 214 (3.2%) | 614 (3.0%) |
*Maternal area-level deprivation was based on postcode of residence and derived according to the standard measure used by the Scottish Government (Scottish Index of Multiple Deprivation [SIMD]).
**Women were classified as clinically extremely vulnerable if they were identified on the national highest risk/shielding list maintained by Public Health Scotland 46 and, of those not extremely vulnerable, were classified as clinically vulnerable if they were in any Q-COVID risk group 47 (excluding diabetes) or had hypertension.