Table 6.

Odds ratios for the association between SARS-CoV-2 infection and major congenital anomalies among babies reaching at least 12 weeks gestation, calculated using conditional logistic regression models

	N pregnancies	N total babies	N babies with any major congenital anomaly	Total prevalence (/1000 total babies)	OR (95% CI)*	p value*	Adjusted OR (95% CI)**	p value**
Any major congenital anomaly
Uninfected	4719	4722	85	18.0	1		1
Infected	1551	1574	32	20.3	1.13 (0.75–1.70)	0.56	1.02 (0.66–1.60)	0.92
Any non-genetic major congenital anomaly
Uninfected	4719	4722	71	15.0	1		1
Infected	1551	1574	26	16.5	1.10 (0.70–1.73)	0.68	0.94 (0.57–1.54)	0.80

OR odds ratio, CI confidence interval

*Accounting for matching factors: maternal age at conception, season of conception and gestational week at matching

**Additionally adjusted for: maternal deprivation, maternal ethnicity, maternal urban rural status, maternal clinical vulnerability, maternal diabetes, maternal smoking status, maternal body mass index and whether the baby was from a singleton or multiple pregnancy