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. 2023 Jan 6;13:306. doi: 10.1038/s41598-022-27281-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LASV antibody epitope mapping based on SP-IRIS data. Top image shows the surface view of LASV GP monomer structure. GP1 is colored yellow and GP2 is colored white. Epitope color code: GP1-A and GP1-B, blue; GP2-A and GP2-B, green; GP2-L1-3, purple; GPC-A, red; and GPC-B, orange. The location of the conformational epitope of GPC-C, where 8.9F binds, is unknown. Reproduced with permission from ⁴⁹. Bottom table groups the LASV antibodies based on their binding levels on SP-IRIS. The only Group 1 antibody 8.9F binds to a unique region in GPC-C and it is the only antibody that showed a strong binding on SP-IRIS. Group 2 antibodies show intermediate binding on SP-IRIS and mainly binds to the GP1 region of the glycoprotein. Group 3 antibodies, which show little or no binding on SP-IRIS, mostly binds to GPC-B and also GP2-L1 and GP2-L3 linear regions.