Table 1.

mAbs against EBOV GP, their relative signal on SP-IRIS, binding domains on the GP, and neutralization activities.

Anti-EBOV GP Ab	Signal on SP-IRIS	Binding domain	Neutralization activity
13F6	+  +  +  +	Mucin-like domain	Non-neutralizing
13C6	+  +  +	Glycan cap	Non-neutralizing
6D8	+  +  +	Mucin-like domain	Non-neutralizing
1H3	+  +  +	Glycan cap	Non-neutralizing
4G7	+  +	GP1/GP2 (base)	Neutralizing
2G4	+  +	GP1/GP2 (base)	Neutralizing
KZ52	+  +	GP1/GP2 (base)	Neutralizing
15H10	+	GP2 (HR2/MPER)	Non-neutralizing
3F10	+	Unknown	Non-neutralizing*
16F6	−	GP1/GP2 (base)	Neutralizing*

The degree of binding is denoted by + /- symbols: +  +  +  + very high, +  +  + high, +  + medium, + little, − no binding.

*Neutralization tests for 3F10 and 16F6 were performed by USAMRIID.