Table 2.
Biochemical characteristics of both groups.
| Parameter {Mean ± SD or Median (IQR)}, (n) | Total (n = 1040) |
Survivors (n = 770) |
Non-Survivors (n = 270) |
p-Value |
|---|---|---|---|---|
| CRP (mg/L) (1036) | 61.9 (24.2–126.7) | 54.4 (19.4–119.3) | 84.2 (47–164.5) | <0.0001 |
| D-dimer (µg/L) (1001) | 1030 (580–2120) | 907 (510–1820) | 1480.5 (860–2906) | <0.0001 |
| ALT (U/L) (1003) | 31 (19–51) | 30 (20–50) | 31 (18–53) | 0.9706 |
| AST (U/L) (1003) | 39 (27–63) | 36 (26.5–56.5) | 51 (31–90) | <0.0001 |
| APTT(s) (997) | 30.9 ± 11.9 | 31 ± 12.4 | 30.8 ± 10 | 0.2138 |
| pH (650) | 7.43 ± 0.08 | 7.44 ± 0.07 | 7.40 ± 0.09 | <0.0001 |
| pCO2 (mmHg) (631) | 34.95 ± 7.56 | 34.53 ± 6.01 | 35.75 ± 9.85 | 0.6865 |
| pO2 (mmHg) (634) | 68.73 ± 30.44 | 67.64 ± 25.32 | 70.79 ± 38.35 | 0.1451 |
| Glucose (mg/dL) (978) | 121 (102–153) | 115 (99–139) | 141 (114–189) | <0.0001 |
| Creatinine (mg/dL) (1032) | 0.92 (0.72–1.23) | 0.86 (0.69–1.09) | 1.17 (0.83–1.7) | <0.0001 |
| eGFR (mL/min/1.73 m2) (1032) | 72.81 ± 28.53 | 78.22 ± 26.86 | 57.15 ± 27.46 | <0.0001 |
| Urea (mg/dL) (942) | 26.45 (16.6–44) | 22.2 (15.2–35.4) | 45.05 (29.3–75) | <0.0001 |
| RBC (million/mm3) (1036) | 4.29 ± 0.72 | 4.32 ± 0.69 | 4.19 ± 0.77 | 0.0036 |
| WBC (thousand/µL) (1036) | 6.72 (4.76–9.1) | 6.3 (4.61–8.51) | 7.97 (5.48–11.7) | <0.0001 |
| Hemoglobin (g/dL) (1036) | 12.93 ± 2.17 | 12.99 ± 2.07 | 12.74 ± 2.44 | 0.1973 |
| Hematocrit (%) (1036) | 38.02 ± 6.21 | 38.11 ± 5.96 | 37,76 ± 6,89 | 0.4113 |
| MCV (fL) (1036) | 88.92 ± 6.75 | 88.51 ± 6.59 | 90.10 ± 7.05 | <0.0001 |
| PLTx109 per L (1036) | 229.2 ± 105 | 235.3 ± 108.2 | 211.6 ± 93 | 0.0007 |
| Neutrophils (%) (1021) | 73.42 ± 15.1 | 71.1 ± 14.84 | 80.18 ± 13.80 | <0.0001 |
| Lymphocytes ×109 per L (822) | 12.95 (1.8–23.7) | 15.2 (4.8–25.2) | 5.3 (1–15.5) | <0.0001 |
| RDW-CV% (1034) | 14.17 ± 3.84 | 13.98 ± 4.24 | 14.75 ± 2.2 | <0.0001 |
| PDW% (1027) | 13.1 ± 3.53 | 13.01 ± 3.74 | 13.37 ± 2.80 | 0.0625 |
| MPV% (1027) | 10.91 ± 3.07 | 10.91 ± 3.50 | 10.9 ± 1.16 | 0.1973 |
| NT-proBNP (pg/mL) (855) | 632 (186.9–2372) | 438.9 (144.5–1596) | 2253.5 (641.1–7062) | <0.0001 |
| INR (1013) | 1.15 (1.06–1.28) | 1.15 (1.06–1.26) | 1.2 (1.07–1.34) | 0.0029 |
| PT(s) (1010) | 12.8 (11.5–14.2) | 12.7 (11.5–14) | 12.9 (11.5–14.7) | 0.0273 |
| Potassium (mg/dL) (1033) | 4.06 ± 0.66 | 4 ± 0.61 | 4.22 ± 0.76 | <0.0001 |
| Procalcitonin (µg/L) (891) | 0.11 (0.06–0.29) | 0.09 (0.05–0.2) | 0.29 (0.12–0.79) | <0.0001 |
| Sodium (mg/dL) (1033) | 137.97 ± 5.64 | 137.69 ± 5.12 | 138.76 ± 6.88 | 0.1502 |
| TSH (mlU/L) (548) | 0.96 (0.52–1.62) | 0.98 (0.58–1.63) | 0.83 (0.36–1.59) | 0.0735 |
| Troponin T (ng/L) (315) | 20 (11–43) | 14 (9–27) | 38.5 (23–79) | <0.0001 |
| Ferritin (µg/L) (535) | 411 (204–819) | 379.5 (192.5–755.5) | 551 (275–1500) | 0.0042 |
| Computed tomography (%) (839) | 25 (10–45) | 20 (10–40) | 40 (15–70) | <0.0001 |
| Serum ferritin (µg/L) (535) | 411 (204–819) | 379.5 (192.5–755.5) | 551 (275–1500) | 0.0042 |
| SpO2 (%) (826) | 90.31 ± 8.44 | 91.63 ± 6.55 | 85.04 ± 12.29 | <0.0001 |
| PaO2/FiO2 (mmHg) (1026) | 276.2 (166.7–380.9) | 304.8 (216.7–428.6) | 186.7 (76.8–276.2) | <0.0001 |
RBC—red blood cells; WBC—white blood cells; CRP—C-reactive protein; PCT—procalcitonin; AST—aspartate transaminase; ALT—alanine transaminase; APTT –- activated partial thromboplastin time; PT—prothrombin time; NT-proBNP—N-terminal prohormone of brain natriuretic peptide; RDW—red blood cell distribution width; PDW—platelet distribution width; MPV—mean platelet volume; SpO2—oxygen saturation at admission, (PaO2/FiO2)—oxygenation index.