. 2023 Jan 6;18(1):e0279928. doi: 10.1371/journal.pone.0279928

Table 9. Top 20 significant AKI-correlated medication pairs for two subgroups.

CKD, GFR<90 Group			Non-CKD GFR≥ 90 Group
Medication Pairs		Pearson Coefficient	Medication Pairs		Pearson Coefficient
Medication 1	Medication 2		Medication 1	Medication 2
Acetazolamide	Fentanyl	0.1106708	Etomidate	Vancomycin	0.13013489
Insulin^*	Vasopressin^*	0.1042989	Furosemide	Levofloxacin/Dext	0.12517537
Calcium Chloride^*	Vasopressin^*	0.10319643	Heparin	Senna	0.12332817
Heparin^*	Norepinephrine^*	0.10296665	Meropenem	Potassium Chloride	0.12137292
Milrinone	Vasopressin	0.09993951	Furosemide^**	Midazolam^**	0.12083589
Midazolam^*	Vasopressin^*	0.09904047	Metronidazole	Vasopressin	0.11958312
Fentanyl^*	Vasopressin^*	0.0989875	Sodium Chloride	Vasopressin	0.11876071
Fentanyl^*	Norepinephrine^*	0.09895096	Fentanyl	Levofloxacin/Dext	0.11670254
Epinephrine	Vasopressin	0.0981826	Dopamine	Pantoprazole	0.11633499
Propofol^*	Vasopressin^*	0.09743555	Furosemide	Vancomycin	0.11594301
Acetazolamide	Potassium Chloride	0.09513354	Cefepime	Vasopressin	0.1143419
Insulin	Milrinone	0.0942025	Etomidate	Piperacillin/Tazobactam Dextrose	0.11387659
Amiodarone^*	Vasopressin^*	0.09379757	Etomidate	Pot Chloride	0.11345592
Calcium Chloride	Milrinone	0.09313112	Midazolam^**	Vancomycin^**	0.11332864
Magnesium Sulfate^*	Vasopressin^*	0.09185513	Etomidate	Furosemide	0.11209237
Epinephrine	Milrinone	0.09170968	Etomidate	Phenylephrine	0.11147296
Insulin^*	Midazolam^*	0.09148049	Etomidate	Vasopressin	0.11103668
Acetazolamide	Lorazepam	0.08859342	Vancomycin	Vasopressin	0.11098672
Potassium Chloride	Vasopressin	0.08796814	Norepinephrine^**	Piperacillin/Tazobactam Dextrose^**	0.11006394
Acetazolamide	Furosemide	0.08789809	Norepinephrine	Sodium Chloride	0.10801834

* AKI-associated medication pairs that were common between the CKD subgroup and the whole cohort.

** AKI-associated medication pairs that were common between the non-CKD subgroup and the whole cohort.