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EVFEtOH and rutaecarpine inhibit 3CL protease activity. EVFEtOH (A) and rutaecarpin (B) both inhibited the activity of the enzyme in a dose-dependent manner. GC376 (100 µM) was used as a positive control. The data represent the mean ± SD percentage of inhibition to the control (with no drug treatment), and n = 4.
